Dynamic Thiol-Disulfide Homeostasis in Children with Newly Diagnosed Iron Deficiency Anemia

نویسندگان

چکیده

Objective: Iron is an element, which found in the structure of antioxidant enzymes and has important role inactivation reactive oxygen species. Disruption oxidant-antioxidant balance may be playing a pathogenesis iron deficiency anemia (IDA). Dynamic thiol-disulfide homeostasis (DTDH) serum ischemia-modified albumin (IMA) levels are indicators pro-oxidant/antioxidant status. In this study, we aimed to evaluate DTDH parameters IMA children with newly diagnosed IDA, who did not receive therapy. Material Methods: Fifty patients IDA 33 healthy age- sex-matched control were included study. groups measured. The same also compared Hb<7 g/dl (profound IDA) (n:14/50, 28%) Hb≥7 (mild-moderate (n: 36/50, 72%) group. relationship between these investigated. Results: Native thiol, total native thiol/total thiol levels, constituting capacity indicators, significantly lower patients; while oxidant disulfide, disulfide/native disulfide/total statistically higher those group (p<0.050). When examined; there was positive correlation negative oxidative hemoglobin ferritin Also, much profound than Hb>7 Conclusion: increase disulfide decrease indicated stress before treatment, Evaluation predicting toxicity due IDA.

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ژورنال

عنوان ژورنال: Türkiye çocuk hastal?klar? dergisi

سال: 2023

ISSN: ['1307-4490', '2148-3566']

DOI: https://doi.org/10.12956/tchd.1196564